Ko, Jin Young,Kim, Ji Yeon,Park, So Hyun,An, Sung Won,Ki, Min Hyo
申请号：
AU2012302422
公开号：
AU2012302422B2
申请日:
2012.08.28
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
Disclosed is a sustained release lipid pre-concentrate, comprising: a) a sorbitan unsaturated fatty acid ester having a polar head with at least two or more -OH (hydroxyl) groups； b) a phospholipid； and c) a liquid crystal hardener, free of an ionizable group, having a hydrophobic moiety of 15 to 40 carbon atoms with a triacyl group or a carbon ring structure. The lipid pre-concentrate exists as a liquid phase in the absence of aqueous fluid and forms into a liquid crystal in the presence of aqueous fluid. Also, a pharmaceutical composition further comprising a pharmacologically active ingredient plus the pre-concentrate is provided.
