METHODS AND COMPOSITIONS FOR INCREASING THE RATIO OF EFFECTIVE T-CELLS TO REGULATORY T-CELLS

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专利权人:

АДВАКСИС, ИНК. (US);НЭЙШНЛ ИНСТИТЬЮТС ОФ ХЭЛС (НИХ), Ю.С. ДЕПТ. ОФ ХЭЛС ЭНД ХЬЮМАН СЕРВИСЕЗ (ДХХС), Ю.С. ГАВЕРМЕНТ НИХ ДИВИЖН ОФ ЭКСТРАМЬЮРАЛ ИНВЕНШНС ЭНД ТЕКНОЛОДЖИ РЕСОРСЕЗ (ДЭИТР) (US); ИНК. (US);АДВАКСИС

发明人:

ПЕТИТ Роберт (US),ВАЛЛЕЧА Ану (US),ЧЭНЬ Чжисон (US),БЭРЗОВСКИ Джэй А. (US),КЛЕЙФ Самир (US)

申请号：

RU2016138601

公开号：

RU2016138601A

申请日:

2015.03.05

申请国别(地区):

RU

年份:

2018

代理人:

摘要：

The present invention is directed to methods for increasing T-cell effector cell to regulatory T cell ratio. The invention is further directed to methods of treating, protecting against, and inducing an immune response against a tumor, comprising the step of administering to a subject a recombinant Listeria strain, comprising a fusion peptide that comprises an LLO fragment and tumor-associated antigen.

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来源网址：

http://www.ckcest.cn/home/