Disclosed are compounds, which have excellent effects of inhibiting DGAT and suppressing food intake, or pharmacologically acceptable salts of the same. Specifically disclosed are 4-carboxymethyl-cyclohexyl trans-6-[3-(2,4-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquin oline-2-carboxylate, 4-carboxymethyl-cyclohexyl trans-6-[3-(2-chloro-phenyl)-ureido]-3,4-dihydro-1H-isoquinolin e-2-carboxylate, 4-carboxymethyl-cyclohexyl trans-6-[3-(2,3-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquin oline-2-carboxylate, 4-carboxymethyl-cyclohexyl trans-6-[3-(2,5-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquin oline-2-carboxylate, 4-carboxymethyl-cyclohexyl trans-6-[3-(2,6-difluoro-phenyl)-ureido]-3,4-dihydro-1H-isoquin oline-2-carboxylate, etc., or pharmacologically acceptable salts of the same.La presente invención se refiere a un compuesto o a una sal farmacológicamente aceptable del mismo que tiene un efecto inhibitorio de DGAT y efecto supresor de la alimentación excelentes la presente invención proporciona éster 4-carboximetil-ciclohexílico de ácido trans-6-[3-(2,4-difluoro-fen il)-ureido]-3,4-dihidro-1H-isoquinolin-2-carboxílico, éster 4-carboximetil-ciclohexílico de ácido trans-6-[3-(2-cloro-fenil)-u reido]-3,4-dihidro-1H-isoquinolin-2-carboxílico, éster 4-carboximetil-ciclohexílico de ácido trans-6-[3-(2,3-difluoro-fen il)-ureido]-3,4-dihidro-1H-isoquinolin-2-carboxílico, éster 4-carboximetil-ciclohexílico de ácido trans-6-[3-(2,5-difluoro-fen il)-ureido]-3,4-dihidro-1H-isoquinolin-2-carboxilico, éster 4-carboximetil-ciclohexílico de ácido trans-6-[3-(2,6-difluoro-fen il)-ureido]-3,4-dihidro-1H-isoquinolin-2-carboxílico, o similares, o una sal farmacológicamente aceptable de los mismos.
