Compuestos y composiciones que son inhibidores de la proteína quinasa

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专利权人:

IRM LLC

发明人:

HUANG, SHENLIN,JIN, XIANMING,LIU, ZUOSHENG,POON, DANIEL,TELLEW, JOHN,WAN, YONGQIN,WANG, XING,XIE, YONGPING

申请号：

ES10748211

公开号：

ES2492499T3

申请日:

2010.08.27

申请国别(地区):

ES

年份:

2014

代理人:

摘要：

A compound selected from: N - [(2S) -1 - ({4- [3- (3-chloro-5-methanesulfonamidophenyl) -1- (propan-2-yl) -1H-pyrazol-4-yl] pyrimidine -2-yl} amino) propan-2-yl] carbamate N - [(2S) -1 - [(4- {3- [3-chloro-5- (propane-1-sulfonamido) phenyl] -1- (propan-2-yl) -1H-pyrazol-4-yl } pyrimidin-2-yl) amino] pro pan-2-yl] carbamate N - [(2S) -1 - ({4- [3- (3-chloro-2-metanosulfonamidopiridin-4-yl) -1- (propan-2-yl) -1H-pyrazol-4-yl] pyrimidine 2-yl} amino) pr opan-2-yl] carbamate N - [(2S) -1 - ({4- [3- (3-fluoro-2-metanosulfonamidopiridin-4-yl) -1- (propan-2-yl) -1H-pyrazol-4-yl] pyrimidine 2-yl} amino) pr opan-2-yl] carbamate N - [(2S) -1 - ({4- [3- (2-chloro-3-ethanesulphonamido-4,5-difluorophenyl) -1- (propan-2-yl) -1H-pyrazol-4-yl] pyrimidin-2-yl} amin o) propan-2-yl] carbamate N - [(2S) -1 - ({4- [3- (2,4-difluoro-3-methanesulfonamidophenyl) -1- (propan-2-yl) -1H-pyrazol-4-yl] pyrimidin-2- yl} amino) pro pan-2-yl] carbamate N - [(2S) -1 - ({4- [1- (propan-2-yl) -3- (2,4,5-trifluoro-3-methanesulfonamidophenyl) -1H-pyrazol-4-yl] pirimi- din-2-yl} amino) propan-2-yl] carbamate N - [(2S) -1 - ({4- [3- (3-methanesulfonamidophenyl) -1- (propan-2-yl) -1H-pyrazol-4-yl] pyrimidin-2-yl} amino) propan 2-yl] carb amate methyl N - [(2S) -1 - [(4- {3- [2,4-difluoro-3- (propane-1-sulfonamido) phenyl] -1- (propan-2-yl) -1H-pyrazol-4 -yl} pyrimidin-2-yl) amino] propan-2-yl] carbamate N - [(2S) -1 - ({4- [3- (3-cyclopropanosulfonamido-2,5-difluorophenyl) -1- (propan-2-yl) -1H-pyrazol-4-yl] pyrimidin-2- yl} amin o) propan-2-yl] carbamate N - [(2S) -1 - ({4- [3- (5-chloro-3-cyclopropanosulfonamido-2-fluorophenyl) -1- (propan-2-yl) -1H-pyrazol-4-yl] pyrimidine 2-yl} a mino) propan-2-yl] carbamate N - [(2S) -1 - [(4- {3- [5-chloro-2-fluoro-3- (propane-1-sulfonamido) phenyl] -1- (propan-2-yl) -1H-pyrazole -4-yl} pyrimidin-2-yl) mino to] propan-2-yl] carbamate N - [(2S) -1 - [(4- {3- [2,6-difluoro-3- (propane-1-sulfonamido) phenyl] -1- (propan-2-yl) -1H-pyrazol-4 -yl} pyrimidin-2-yl) amino] p

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