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DERIVADOS DEL PIRROLO[2,3-B]PIRIDINA PARA LA INHIBICION DE LAS PROTEINAS QUINASAS RAF
- 专利权人:
- PLEXXIKON; INC.
- 发明人:
- IBRAHIM, PRABHA N.,SPEVAK, WAYNE,CHO, HANNA,ZHU, HONGYAO
- 申请号：
- PE0016202011
- 公开号：
- PE01842012A1
- 申请日:
- 2010.03.10
- 申请国别(地区):
- PE
- 年份:
- 2012
- 代理人:
- 摘要：
- Refers to compounds derived from pirrolo [2,3-b] pyridine as: propane sulfonic acid - 1 - {2,4-difluoro-3 - [5 - (2 - methoxy pyrimidin-5-yl) - 1H pyrrolo [2,3-b] carbonyl] - pyridine - 2 - phenyl) - amide propane sulfonic acid - 1 - [3 - (5 - cyano - 1H pyrrolo [2,3-b] pyridine - 2 - 2.4 - difluoro - carbonyl) - phenyl] -. A propane sulfonic acid) - 1 - [3 - (5 - cyano - 1H pyrrolo [2,3 - 3 - B] pyridine - 2 - fluoro carbonyl) - phenyl] - amide n - [3 - (5 - cyano - 1H pyrrolo [2,3-b] pyridine - 2 - carbonyl) - phenyl] - difluoro - 2.4 - 2.5 - difluoro - benzenesulfonamide n - [3 - (5 - cyano - 1h pyrrolo [2,3-b] pyridine - 2 - 2.4 - difluoro - carbonyl) - phenyl] - 3 - fluoro benzene sulfonamide sulfonic acid pyrrolidine - 1 - [3 - (5 - cyano - 1H pyrrolo [2,3-b] pyridine - 2 - 2.4 - difluoro - carbonyl) - phenyl] - amide among others.It also relates to a Pharmaceutical composition. These compounds are inhibitors of the Protein Kinase RAF and RAF, b-raf and c-raf - 1 being useful in the treatment of melanoma, glioma, colorectal cancer, Thyroid cancerSE REFIERE A COMPUESTOS DERIVADOS DE PIRROLO[2,3-b]PIRIDINA TAL COMO: ACIDO PROPANO-1-SULFONICO DE {2,4-DIFLUORO-3-[5-(2-METOXI-PIRIMIDIN-5-IL)-1H-PIRROLO[2,3-b]PIRIDINA-3-CARBONIL]-FENIL}-AMIDA ACIDO PROPANO-1-SULFONICO DE [3-(5-CIANO-1H-PIRROLO[2,3-b]PIRIDINA-3-CARBONIL)-2,4-DIFLUORO-FENIL]-AMIDA ACIDO PROPANO-1-SULFONICO DE [3-(5-CIANO-1H-PIRROLO[2,3-b]PIRIDINA-3-CARBONIL)-2-FLUORO-FENIL]-AMIDA N-[3-(5-CIANO-1H-PIRROLO[2,3-b]PIRIDINA-3-CARBONIL)-2,4-DIFLUORO-FENIL]-2,5-DIFLUORO-BENCENOSULFONAMIDA N-[3-(5-CIANO-1H-PIRROLO[2,3-b]PIRIDINA-3-CARBONIL)-2,4-DIFLUORO-FENIL]-3-FLUORO-BENCENO-SULFONAMIDA ACIDO PIRROLIDINA-1-SULFONICO DE [3-(5-CIANO-1H-PIRROLO[2,3-b]PIRIDINA-3-CARBONIL)-2,4-DIFLUORO-FENIL]-AMIDA ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LAS PROTEINA QUINASAS RAF COMO A-RAF, B-RAF Y c-RAF-1 SIENDO UTILES EN EL TRATAMIENTO DE MELANOMA, GLIOMA, CANCER CO
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
