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derivatives of pyrrolo [2,3-b] pyridine for the inhibition of raf kinases
- 专利权人:
- INC.;PLEXXIKON
- 发明人:
- IBRAHIM, PRABHA N.,SPEVAK, WAYNE,CHO, HANNA,ZHU, HONGYAO
- 申请号：
- MA34228
- 公开号：
- MA33181B1
- 申请日:
- 2011.10.04
- 申请国别(地区):
- MA
- 年份:
- 2012
- 代理人:
- 摘要：
- the invention relates to a propane sulfonic acid - 1 - (2,4 - difluoro - (3 - [5 - (2 - methoxy pyrimidine) - 1h pyrrolo [2,3-b] pyridine) carbonyl] phenyl] - amide, propane sulfonic acid - 1 - [3 - (5) - cyano - 1h pyrrolo [2,3-b] pyridine) carbonyl) - 2.4 - difluoro - phenyl] propane amide, sulfonic acid - 1 - [3 - (5 - cy ano - 1h pyrrolo [2,3-b] pyridine) carbonyl) - fluoro phenyl) - amide, n - [3 - (5) - cyano - 1h pyrrolo [2,3 - b] pyridine) carbonyl) - 2.4 - difluoro - phenyl] - benzenesulfonamide 2,5-difluoro-4 -, n - [3 - (5) - cyano - 1h pyrrolo [2,3-b] pyridine) carbonyl) - 2.4 - difluoro - phenyl] - 3 - fluoro benzene. pyrrolidine sulfonic acid - 1 - [3 - (5) - cyano - 1h pyrrolo [2,3-b] pyridine) carbonyl) - 2.4 - difluoro - phenyl]. of the n, n - dimethylamino - sulfonic acid, [3 - (5 - cyano - 1h pyrrolo [2,3-b] pyridine) carbonyl) - 2.4 - difluoro - phenyl) - amide, and salts thereof, formulations, conjugates, derivatives thereof, forms and their uses. in certain aspects and embodiments, the compounds according to the invention, or salts thereof, formulations, conjugates, derivatives thereof, and their forms are active on at least one raf protein kinase.the invention also relates to processes for use in the treatment of diseases and conditions, including diseases and conditions associated with protein kinase activity of raf, including melanoma, glioma, colorectal cancer, thyroid cancer, lung cancer, c launch of the ovary, prostate cancer, and cancer of the biliary tract.L'invention concerne le propane-1-acide sulfonique {2,4-difluoro-3-[5-(2-méthoxy-pyrimidine-5-yl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-phényl}-amide, le propane-1-acide sulfonique [3-(5-cyano-1h-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phényl]-amide,le propane-1-acide sulfonique [3-(5-cyano-1h-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phényl]-amide, le n-[3-(5-cyano-1h-pyrrolo[2,3-b] pyridine-3-carbonyl)-2,4-difluoro-phényl]-2,5-difluoro-benzènesulfonamide,le n-[3-(5-cyano-1
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
