PROPANE-1-SULFONIC ACID {2,4-DIFLUORO-3-[5-(2-METHOXY-PYRIMIDIN-5-YL)-1H-PYRROLO [2,3-B]PYRIDINE-3-CARBONYL]-PHENYL}-AMIDE, PROPANE-1-SULFONIC ACID [3-(5-CYANO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL)-2,4-DIFLUORO-PHENYL]-AMIDE, PROPANE-1-SULFONIC ACID [3-(5-CYANO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL)-2-FLUORO-PHENYL]-AMIDE, N-[3-(5-CYANO-1H-PYRROLO[2,3-B] PYRIDINE-3-CARBONYL)-2,4-DIFLUORO-PHENYL]-2,5-DIFLUORO-BENZENESULFONAMIDE, N-[3-(5-CYANO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL)-2,4-DIFLUORO-PHENYL)-3-FLUORO-BENZENESULFONAMIDE, PYRROLIDINE-1-SULFONIC ACID [3-(5-CYANO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL)-2,4-DIFLUORO-PHENYL]-AMIDE,N,N-DIMETHYLAMINO-SULFONIC ACID [3-(5-CYANO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL)-2,4-DIFLUORO-PHENYL]-AMIDE, AND SALTS THEREOF, FORMULATIONS THEREOF, CONJUGATES THEREOF, DERIVATIVES THEREOF, FORMS THEREOF AND USES THEREOF ARE DESCRIBED. IN CERTAIN ASPECTS AND EMBODIMENTS, THE DESCRIBED COMPOUNDS OR SALTS THEREOF, FORMULATIONS THEREOF, CONJUGATES THEREOF, DERIVATIVES THEREOF, AND FORMS THEREOF ARE ACTIVE ON AT LEAST ONE RAF PROTEIN KINASE. ALSO DESCRIBED ARE METHODS OF USE THEREOF TO TREAT DISEASES AND CONDITIONS, INCLUDING DISEASES AND CONDITIONS ASSOCIATED WITH ACTIVITY OF RAF PROTEIN KINASES, INCLUDING MELANOMA, GLIOMA, COLORECTAL CANCER, THYROID CANCER, LUNG CANCER, OVARIAN CANCER, PROSTATE CANCER, AND BILIARY TRACT CANCER.
