Валерий Алахов (CA),Грзегорз Пиетрзински (CA),Кишоре Пател (CA),Томаз Попек (CA)
申请号：
RU2013107115/15
公开号：
RU2013107115A
申请日:
2011.02.23
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. A composition comprising bendamustine first charged tsiklopolisaharid having at least one charged group and a stabilizing agent that is a second charged tsiklopolisaharid having at least one charged group, said second tsiklopolisaharid has a charge opposite the first charged tsiklopolisaharida.2. A composition according to claim 1, characterized in that said first charged tsiklopolisaharid represents tsiklodekstrin.3. A composition according to claim 2, characterized in that at least one charged group of the first charged tsiklopolisaharida is an anionic gruppu.4. Composition according to claim 3, characterized in that the said anionic group is selected from the group consisting of sulfate, sulfonyl and karbonil.5. A composition according to claim 4, wherein the first charged tsiklopolisaharid selected from the group consisting of sulfobutyl ether beta-cyclodextrin sodium salt of carboxymethyl-beta-cyclodextrin, sodium salt of O-phosphate-beta-cyclodextrin, succinyl (2- hydroxy) propyl -beta-cyclodextrin, sodium salt of sulfopropyl-beta-cyclodextrin and sodium sulfate-O-beta-tsiklodekstrina.6. A composition according to claim 5, characterized in that said first charged tsiklopolisaharid is sulfobutyl ether beta-tsiklodekstrina.7. A composition according to claim 3, characterized in that at least one charged group stabilizing agent is selected from the group consisting of amine, guanidine and quaternary ammoniy.8. A composition according to claim 7, characterized in that said first charged tsiklopolisaharid selected from the group consisting of hexakis (6-amino-6-deoxy) alpha tsiklodeks1. Композиция, включающая бендамустин первый заряженный циклополисахарид, имеющий, по крайней мере, одну заряженную группу и стабилизирующий агент, который представляет собой второй заряженный циклополисахарид, имеющий, по крайней мере, одну заряженную группупричем указанный второй циклополисахарид имеет заряд, противоположный заряду первого заряженного циклополисахарида.2. Композиц
