IZUMIMOTO, NAOKI,KOMAGATA, TOSHIKAZU,HONDA, TOSHIYUKI,KAWAI, KOJI
申请号：
CA2561509
公开号：
CA2561509C
申请日:
2005.03.30
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
A novel antipruritic useful for the treatment of pruritus accompanying variousdiseases is disclosed. The antipruritic comprises a specific morphinanderivativehaving a nitrogen-containing cyclic group or the pharmaceutically acceptableacidaddition salt thereof such asN-(17-cyclopropylmethyl-4,5.alpha.-epoxy-3,14-dihydroxy--morphinan-6.beta.-yl)-phthalimidehydrochloric acid salt(see formula 1)or N-(17-cyclopropylmethyl-4,5.alpha.-epoxy-3,14-dihydroxy-morphinan-6.beta.-yl)-3,4,5,6--tetrahydrophthalimide tartaric acid salt.
