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Pyrazole Derivatives, compositions containing these compounds and use
专利权人:
MERCK SHARP & DOHME CORP.
发明人:
申请号:
ARP120104354
公开号:
AR088919A2
申请日:
2012.11.20
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
These compounds contribute to the treatment of type 2 diabetes and related diseases. It also includes drug ingredients and treatment procedures. 1. Claim 1: a compound with the characteristics of (1) formula or selected from a group of substances composed of (a) halo, oh, co832228; r83088, each R 1 is h;Cn, so 8346r83090 or no832229;(b) C₁₋₆-alkyl or O-C₁₋₆-alkyl optionally substituted with (I) 1-5 halo groups to a perhaloalkyl group; (II) CO₂R⁴;(III) phenyl optionally substituted as follows: (i) 1-5 halo groups, (ii) 1 CO₂R⁴ group,CN S (O) RNO o C (O) NR R(Iii) 1 - 2 grupos alquilo o alcoxi C1. Each substitute is: 1-5 brine to perhalogue and 1-2 Oh or co83228r8308;2. Each R2 is selected from R 1 specified above, or two R2 groups together represent a cyclic structure, which is composed of 5-6 concentrated members, including 1-2 oxygen atoms and 1-2 carbon atoms. Each carbon atom can optionally be replaced by 1-2 F atoms; R3 is h or c831832323;R8308es h, c1832131, block 832626;and R⁵ represents a member selected from the group consisting of: C₁₋₁₀ alkyl,aryl or Ar-C₁₋₁₀ alkyl;R⁶ and R⁷ each independently represent H or C₁₋₃ alkyl,P is 0, 1 or 2; arilo and Ar are single or double ring aromatic rings containing 6-12 carbon atoms.Los compuestos son útiles para tratar la diabetes de tipo 2 y dolencias relacionadas. También se incluyen composiciones farmacéuticas y procedimientos de tratamiento. Reivindicación 1: Un compuesto caracterizado porque está representado por la fórmula (1) o una sal farmacéuticamente aceptables del mismo, en el que: cada R¹ es H o se selecciona del grupo constituido por: (a) halo, OH, CO₂R⁴, CN, SOₚR⁵ o NO₂, (b) alquilo C₁₋₆ o O-alquilo C₁₋₆ opcionalmente sustituido con (I) 1 - 5 grupos halo hasta un grupo perhaloalquilo; (II) CO₂R⁴; (III) fenilo opcionalmente sustituido como sigue: (i) 1 - 5 grupos halo, (ii) 1 grupo CO₂R⁴, CN, S(O)ₚR⁵, NO₂ o C(O)NR⁶R⁷, (iii) 1 - 2 grupos alquilo o alcoxi C₁₋₁₀, cada uno opcionalmente sustituido con: 1 - 5 halo
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