브라운 매튜 프랭크,데르멘치 알파이,펜섬 앤드류,저스텐버거 브라이언 스티븐,헤이워드 매튜 메릴,오웬 다피드 리스,롸이트 스티븐 웨인,싱 리 후앙,양 샤오징
申请号：
KR1020187024431
公开号：
KR1020180103158A
申请日:
2017.02.10
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
There is provided a compound having the structure of formula (I) or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or said pharmaceutically acceptable salt: Wherein A, A 'and A "are independently O, C = O, CR' or NR", wherein R 'and R "are independently H, amino, -NR 7 COR 6 , COR 6 , -CONR 7 R 8, C 1 -C 6 alkyl, or hydroxy (C 1 -C 6 alkyl) may be, R "is present, or is present in the case of can members, allows the law of atoms a, a ' And A " is O or C = O； R 0 and R are independently H, Br, Cl, F or C 1 -C 6 alkyl； R 1 is H, C 1 -C 6 alkyl , or hydroxy (C 1 -C 6 alkyl)； R 2 is H, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, hydroxy (C 1 -C 6 alkyl), phenyl (C 1 -C from (CH 2)n -W group consisting of - 6 alkyl), formyl, heteroaryl, heterocyclic, -COR 6, -OCOR 6, -COOR 6, -NR 7 COR 6, -CONR 7 R 8, and selected, and wherein W is cyano, hydroxy, C 3 -C 8 cycloalkyl, -SO 2 NR 7 and R 8, or -SO 2 -R 9, R 9 is C 1 -C 6 alkyl, C 3 - C 8 cycloalkyl, heteroaryl, Is heterocyclic, wherein alkyl, cycloalkyl, heterocyclic, or heteroaryl each of which unsubstituted or substituted by halo, cyano, hydroxy, or C 1 -C 6 alkyl may be substituted with, and； X is CR 3, or N, wherein R 3 can be H or C 1 -C 6 alkyl； R 4 and R 5 are independently H, amino, C 1 -C 6 alkyl, or hydroxy (C 1 -C 6 alkyl) R 6 , R 7 and R 8 are each independently H, C 1 -C 6 alkyl, C 1 -C 4 alkoxy (C 1 -C 6 alkyl), or C 3 -C 8 cycloalkyl, C 1 -C 6 alkyl is optionally substituted with halo, CN or hydroxy； or R 7 and R 8 , together with the atoms bonded thereto, form a 5-or 6-membered ring, Halo, hydroxy, CN, or C 1 -C 6 alkyl； n is 0, 1, 2 or 3； Also provided are methods of treatment as Janus kinase inhibitors, and pharmaceutical compositions containing compounds of the invention or other therapeutic agents and combinations thereof.하기 화학식 (I)의 구조를 갖는 화합물 또는 이의 약학적으로 허용가능한 염, 또는 상기 화합물 또는 상기 약학적으로 허용가능한 염의 약학적으로 허용가능한 용매화물이 제공된다:상기 식에서, A, A' 및 A"는 독립적으로 O, C=O, C-R' 또
