Pharmaceutical ingredients that include these compounds and salts, and the use of these compounds, salts, and compounds to treat abnormal cell growth, including cancer. 1. Claim 1: a formula compound (1),Or a salt acceptable for medicine, wherein: n or Cr cube；V is n / cr830808；R1 is apartment c83217c83318328a,C₁₋₈ alkoxy,Halo, oh, cn-o-nr8311； r831222；wherein each C₁₋₈ alkyl or C₁₋₈ alkoxy is optionally substituted by one or more R²¹；R² is selected from the group consisting of H, C₁₋₈ alkyl,C₁₋₈ alkoxy,-Or8310,-8311； 831222；-C (o) No. 8311； (r83212)；-So8322； No. 8311； r831222；-No. 8311； No. so8322； No. 831222；C₃₋₈ cycloalkyl,3-12 membered heterocyclyl, C₆₋₁₂ aryl and 5-12 membered heteroaryl, wherein each C₁₋₈ alkyl or C₁₋₈ alkoxy is optionally substituted by one or more R²²,and each C₃₋₈ cycloalkyl,3-12 membered heterocyclyl, C₆₋₁₂ aryl or 5-12 membered heteroaryl is optionally substituted by one or more R³²；R³ is H, C₁₋₈ alkyl,C₁₋₈ alkoxy,Halo, oh, cn-o-nr8311； r831222；wherein each C₁₋₈ alkyl or C₁₋₈ alkoxy is optionally substituted by one or more R²³；R⁴ is selected from the group consisting of H, halo, C₁₋₈ alkyl,C₃₋₈ cycloalkyl,3-12 membered heterocyclyl, C₆₋₁₂ aryl,5-12 membered heteroaryl, - (C₁₋₄ alkyl) Rᶻ,-Or739,-CN -C (O) R-CO₂Rˣ,-C (O) NR R-739；-Sor739th,-SO₂Rˣ,-So8322； - No. 739r696；-No.8322；-No. 739r696；-739； (c) r696；-739； - C (o) 739； - r696；-739； (c) or 696；-739； - so8322； - 696；-739； so8322； 739； r696；-OC (O) R y -OC (O) NR Reach Rˣ and Rʸ is independently selected from the group consisting of H, C₁₋₈ alkyl,C₃₋₈ cycloalkyl,3-12 membered heterocyclyl, C₆₋₁₂ aryl and 5-12 membered heteroaryl； or Rˣ and Rʸ can be taken together with the N atom to which they are attached to form a 3-12 membered heterocyclyl or 5-12 membered heteroaryl ring, each optionally containing 1, 2 or 3 additional heteroatoms selected from O, N and S； each Rᶻ is independently selected from the group consisting of cycloalkyl C₃₋₈,3-12 membered heterocyclyl, C₆₋₁₂ aryl and 5-12 me
