作為FGF受體活化劑之N-醯基八糖，其製備及其治療用途农业专利-农业学术服务平台

发明人:: DRIGUEZ, PIERRE ALEXANDRE,德里格兹　皮尔　亚历山大,德里格茲　皮爾　亞歷山大,DUCHAUSSOY, PHILIPPE,道奇斯索伊　飞利浦,道奇斯索伊　飛利浦,FONS, PIERRE,芳斯　皮尔,芳斯　皮爾,HERBERT, CORENTIN,贺伯特　科伦汀,賀伯特　科倫汀,LASSALLE, GILBERT,拉塞尔　吉勃特,拉塞爾　吉勃特,德里格兹皮尔亚历山大,德里格茲皮爾亞歷山大,道奇斯索伊飞利浦,道奇斯索伊飛利浦,芳斯皮尔,芳斯皮爾,贺伯特科伦汀,賀伯特科倫汀,拉塞尔吉勃特,拉塞爾吉勃特

摘要：: N-Acyl octasaccharides that activate the FGF receptors, corresponding to formula (I):in which:- R1 represents a group O-alkyl optionally substituted with one or more alkyl or cycloalkyl groups,- R2 represents a group OSO3- or a hydroxyl group,- R3 represents an alkyl, cycloalkyl or alkyl-cycloalkyl group, and- R4 represents a disaccharide of formula (II), R6 represents a disaccharide of formula (III) and R8 represents a disaccharide of formula (IV), in which R5, R7 and R9 represent OSO3- or hydroxyl groups:Their preparation and their therapeutic use.會活化FGF受體之N-醯基八糖，其係相應於式(I)：其中：- R1表示視情況被一或多個烷基或環烷基取代之基團O-烷基，- R2表示基團OSO3-或羥基，- R3表示烷基、環烷基或烷基-環烷基，且- R4表示式(II)二醣，R6表示式(III)二醣，且R8表示式(IV)二醣，其中R5、R7及R9表示OSO3-或羥基：其製備及其治療用途。