PROBLEM TO BE SOLVED: To provide a production method of a cyclic amino benzoic acid derivative which is an excellent agonist of a human peroxiosome proliferative-agent receptor (PPAR), is high in efficiency and suitable for industrial production.SOLUTION: The two-nitro benzoic acid ester derivative and a piperidine derivative are made to react with each other, and after reducing a nitro group of an obtained compound, a deamination reaction is performed by using a nitrous acid or its salt and a reducer. Thus, the cyclic aminobenzoic acid derivative being the PPARα agonist and its hydrate are produced.COPYRIGHT: (C)2012,JPO&INPIT【課題】ヒトペルオキシゾーム増殖薬活性化受容体(PPAR)の優れたアゴニストである環状アミノ安息香酸誘導体の、効率的かつ工業生産に適した製造方法を提供する。【解決手段】2-ニトロ安息香酸エステル誘導体とピペリジン誘導体を反応させ、得られた化合物のニトロ基を還元後、亜硝酸またはその塩と還元剤により脱アミノ化反応を行うことにより、PPARαアゴニストである環状アミノ安息香酸誘導体及びその水和物を製造する。【選択図】 なし
