Ahmed M. Naglah,Abd El-Galil E. Amr,Mohamed A. Al-Omar
申请号：
US15815587
公开号：
US09969768B1
申请日:
2017.11.16
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Oleanolic acid methyl ester derivatives demonstrate potent anti-diabetic activities. In in vitro anti-diabetic testing, the derivatives showed more potency regarding dipeptidyl peptidase-4 (DPP-IV) inhibitor activity, peroxisome proliferator-activated receptors (PPARs) agonist activity, and α-Glucosidase inhibitors activity, as compared to reference standards oleanolic acid and acarbose. In in vivo oral hypoglycemic testing, both acute and sub-acute studies demonstrated that the derivatives had high potency and long duration of action compared to the reference standards pioglitazone, acarbose and oleanolic acid.
