RABOISSON, PIERRE JEAN-MARIE BERNARD,DE KOCK, HERMAN AUGUSTINUS,HU, LILI,SIMMEN, KENNETH ALAN,LINDQUIST, KARIN CHARLOTTA,LINDSTROM, MATS STEFAN,BELFRAGE, ANNA KARIN GERTRUD LINNEA,WAHLING, HORST JURGE
申请号：
CA2617103
公开号：
CA2617103C
申请日:
2006.07.28
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Compounds of the formula (I), and N-oxides, salts, and stereoisomers thereofwherein A is OR1, NHS(=O)PR2 wherein R1 is hydrogen, C1-C6alkyl, C0-C3alkylenecarbocyclyl, C0-C3alkylene-heterocyclyl R2 is C1-C6alkyl, C0-C3alkylenecarbocyclyl, C0-C3alkyleneheterocyclyl p is independently 1 or 2 nis 3, 4, 5 or 6 ---- deonotes an optional double bond L is N or CRz Rz is Hor forms a double bond with the asterisked carbon Rq is H or when L is CRz,Rq can also be C1-C6alkyl Rr is quinazolinyl, optionally substituted with onetwo or three substituents each independently selected from C1-C6 alkyl, C1-C6alkoxy, hydroxyl, halo, haloC1-C6alkyl, amino, mono- or dialkylamino, mono-or dialkylaminocarbonyl, C1-C6alkyl- carbonylamino, C0-C3alkylenecarbocyclyland C0-C3 alkyleneheterocyclyl R5 is hydrogen, C1-C6alkyl, C1-C6alkoxyC1-C6alkyl or C3-C7cycloalkyl R6 is hydrogen, C1-C6alkyl, C1-C6alkoxy, C0-C3alkylenecarbocyclyl, C0-C3alkyleneheterocyclyl, hydroxy, bromo, chloro orfluoro have utility in the treatment or prophylaxis of flaviviral infectionssuch as HCV.
