Lindquist, Karin Charlotta,De Kock, Herman Augustinus,Kahnberg, Pia Cecilia,Hu, Lili,Rosenquist, Asa Annica Kristina,Raboisson, Pierre Jean-Marie Bernard,Sahlberg, Sven Crister,Lindstrom, Mats Stefan
申请号：
AU2006274866
公开号：
AU2006274866B2
申请日:
2006.07.28
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Compounds of the formula (I), and N-oxides, salts, and stereoisomers thereofwherein A is OR, NHS(=O)R； wherein； Ris hydrogen, C-Calkyl, C-Calkylenecarbocyclyl,C-Calkylene-heterocyclyl； R is C-Calkyl,C-Calkylenecarbocyclyl, C-Calkyleneheterocyclyl；p is independently 1 or 2； n is 3, 4, 5 or 6； ---- deonotes an optional double bond；L is N or CRz； Rz is H or forms a double bond with the asterisked carbon； Rq is H or whenL is CRz, Rq can also be C-Calkyl； Rr is quinazolinyl, optionallysubstituted with one two or three substituents each independently selectedfrom C-C alkyl, C-Calkoxy, hydroxyl,halo, haloC-Calkyl, amino, mono- or dialkylamino, mono-or dialkylaminocarbonyl, C-Calkyl- carbonylamino,C-Calkylenecarbocyclyl and C-Calkyleneheterocyclyl； R is hydrogen, C-Calkyl,C-CalkoxyC-Calkyl or C-Ccycloalkyl；R is hydrogen, C-Calkyl, C-Calkoxy,C-Calkylenecarbocyclyl, C-Calkyleneheterocyclyl,hydroxy, bromo, chloro or fluoro have utility in the treatment or prophylaxisof flaviviral infections such as HCV.
