生体分子を表面に固定したアパタイト被覆生体インプラント及び細胞培養担体
- 专利权人:
- 独立行政法人産業技術総合研究所
- 发明人:
- 稲垣 雅彦,斎藤 隆雄,亀山 哲也
- 申请号：
- JP2008061886
- 公开号：
- JP5234743B2
- 申请日:
- 2008.03.11
- 申请国别(地区):
- JP
- 年份:
- 2013
- 代理人:
- 摘要：
PROBLEM TO BE SOLVED: To provide a biological implant, such as an artificial joint and an artificial dental root, having basic protein, such as bone morphogenetic protein, fixed on the surface of hydroxyapatite, and to provide a cell culture carrier.
SOLUTION: A biomaterial consists of ceramic primarily composed of hydroxyapatite, wherein a (001) face (c face) of a crystal of the hydroxyapatite HA in the ceramic has a face preferentially exposed to the surface, an orientation by a thin film orientation analysis of XRD of HA (004) surface shows a high crystalline orientation of 13.5° or more and the basic protein is selectively fixed to a part at least near the surface of the applicable face. The biomaterial provides the hydroxyapatite membrane which has a high orientation observed in a dental enamel of a person, and scarcely includes calcium oxide which is supposed to cause inflammation especially in a living body, at least near the surface of the membrane, the biological implant having the membrane, and the cell culture carrier.
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- 来源网站：
- 中国工程科技知识中心
