Guisen Zhang;Linjie Zhang;Guan Wang;Xiangping Yang;Xiangqing Xu;Yumei Wang;Peng Xie;Jianqi Li
发明人:
Jianqi Li,Guan Wang,Guisen Zhang,Xiangping Yang,Peng Xie,Linjie Zhang,Xiangqing Xu,Yumei Wang
申请号：
US13141803
公开号：
US08778948B2
申请日:
2009.12.22
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention relates to a substituted phenylpiperazine aryl alkanol derivative represented by the following general formula and its salt and hydrate,wherein C1 and C2 represent chiral carbon atoms, and the compound is one of the six isomers: (1RS, 2SR), (1RS, 2RS), (1R, 2S), (1S, 2S), (1R, 2R) or (1S, 2R)； and R, R1, R2, R3 and Ar are as defined in the specification. The derivative is non-opioid analgesic, has good analgesic effect and relatively small side effects. The invention also relates to a composition comprising the derivative and its use.
