Eliezer de Jesus De Lacerda Barreiro;Luiz Antonio Soares Romeiro;Ana Luisa Palhares Miranda;Carlos Alberto Manssour Fraga;Eduardo Vera Tibiriçá;Fernanda Carla Ferreira d;Cláudia Lúcia Martins da Silva
发明人:
Luiz Antonio Soares Romeiro,Carlos Alberto Manssour Fraga,Eliezer de Jesus De Lacerda Barreiro,Cláudia Lúcia Martins da Silva,Ana Luisa Palhares Miranda,Eduardo Vera Tibiriçá,Fernanda Carla Ferreira d
申请号：
US13471634
公开号：
US20120232094A1
申请日:
2012.05.15
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention describes phenylpiperazinyl alpha adrenergic antagonists that corresponds to the formula (I)which selectively act on the alpha 1A/alpha 1D subtypes, where its selectivity index in comparison to alpha 1B subtype is, at minimum, 1700 for the alpha 1A subtype and 10000 for the alpha 1D subtype, being therefore useful for the treatment of the lower urinary tract symptoms, including the benign prostatic hyperplasia treatment in mammals, preferentially humans. Also described are pharmaceutical compositions containing said compounds and methods for its preparation.
