CORTE, James R.,EWING, William R.,PINTO, Donald J. P.,SMITH II, Leon M.
申请号：
ES16750350
公开号：
ES2754599T3
申请日:
2016.08.03
申请国别(地区):
ES
年份:
2020
代理人:
摘要：
A compound of Formula (I): ** Formula ** or a stereoisomer, a tautomer, a pharmaceutically acceptable salt thereof, wherein: A is independently selected from ** Formula ** and Hal is halogen； R1 and R2 are independently selected from H, halogen, CN, NRaRa, C1-6 alkyl substituted with 1-5 R10, - ORb, -C (= O) Rb, -C (= O) ORb, - (CH2) n -aryl substituted with 1-5 R10, - (CH2) n-cycloalkyl C3-6 substituted with 1-5 R10 and - (CH2) n-heterocyclyl of 4-6 members substituted with 1-5 R10； R3 is independently selected from C1-4 alkyl substituted with 1-5 R5, - (CH2) n-carbocyclyl C3-10 substituted with 1-5 R5 and - (CH2) n-heterocyclyl 4-10 membered substituted with 1-5 R5 ； R4 is independently selected from H and C1-4alkyl substituted with 1-5 R6； alternatively, R3 and R4 together with the nitrogen atom to which they are both attached form a heterocyclic ring substituted with 1-5 R5； R5, in each case, is independently selected from H, halogen, C1-5 alkyl substituted with 0-5 Re, = O, - (CH2) nCN, - (CH2) n-ORb, - (CH2) n-NRaRa, - (CH2) nC (= O) Rb, - (CH2) nC (= O) ORb, - (CH2) nC (= O) NRaRa, - (CH2) n- C (= NH) NHRa, - (CH2) n-NRaC (= O) ORb, - (CH2) n-NRaC (= O) Rb, - (CH2) n-NRaC (N-CN) NHRa, - (CH2) n-NRaC (NH) NHRa, - ( CH2) nN = CRbNRaRa, - (CH2) n-NRaC (= O) NRaRa, - (CH2) nC (= O) NRaRa, - (CH2) n-NRaC (= S) NRaC (= O) Rb, - ( CH2) n- S (= O) pRc, - (CH2) nS (= O) pNRaRa, - (CH2) n-NRaS (= O) pNRaRa, - (CH2) n-NRaS (= O) pRc, - ( CH2) C3-10 n-carbocyclyl substituted with 1-5 R6, - (CH2) 4- to 10-membered n-heterocyclyl substituted with 1-5 R6 and -O-4- to 10-membered heterocyclyl substituted with 1-5 R6； R6, in each case, is independently selected from H, - (CH2) n-ORb, = O, - (CH2) nNH2, - (CH2) nCN, halogen, C1-6 alkyl substituted with 0-5 Re, - ( CH2) nC (= O) ORb, - (CH2) n-ORb, - (CH2) n-C3-10 carbocyclyl and - (CH2) n-heterocyclyl 4-10 membered substituted with 0-5 Re； R7 is independently selected from H, hydroxyl, ORb, halogen, NRaRa, and C1-3 alkyl； R8 i
