CLARKE, Michael O' Neil Hanrahan,CLARKE, Michael O Neil Hanrahan
申请号：
ES13712043
公开号：
ES2621217T3
申请日:
2013.03.11
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of Formula I: ** Formula ** or a pharmaceutically acceptable salt, solvate or ester thereof； wherein: each of R1 and R7 is independently H, halogen, ORa, haloalkyl (C1-C8), halocycloalkyl (C3-C8), CN, N3, alkyl (C1-C8), cycloalkyl (C3-C8), substituted (C1-C8) alkyl, substituted (C3-C8) cycloalkyl, substituted (C2-C8) alkenyl, substituted (C2-C8) alkenyl, substituted (C2-C8) alkynyl or substituted (C2-C8) alkynyl, wherein the substituent is selected from the group consisting of -X, -Rb, -OH,>； = O, -ORb, -SRb, -S-, -NRb2, - N + Rb3,>； = NRb, -CX3, -CN, -OCN , -SCN, -N>； = C>； = O, -NCS, -NO, -NO2,>； = N2, -N3, -NHC (>； = O) Rb, -OC (>； = O) Rb, - NHC ( >； = O) NRb2, -S (>； = O) 2-, -S (>； = O) 2OH, -S (>； = O) 2Rb, -OS (>； = O) 2ORb, -S (>； = O) 2NRb2, -S (>； = O) Rb, -OP (>； = O) (ORb) 2, - P (>； = O) (ORb) 2, -P (>； = O) (O-) 2, -P (>； = O) (OH) 2, -P (O) (ORb) (O-), -C (>； = O) Rb, -C (>； = O) X, -C (S) Rb, -C (O) ORb, -C (O) O-, - C (S) ORb, -C (O) SRb, -C (S) SRb, -C (O) NRb2, -C (S) NRb2, -C (>； = NRb) NRb2, where each X is independently a halogen: F, Cl, Br or I； and each Rb is independently H, alkyl, cycloalkyl, aryl, arylalkyl or a heterocycle； R2 is ORa； R3 is halogen or N3； each Ra is independently H, aryl, arylalkyl, (C1-C8) alkyl, or (C3-C8) cycloalkyl； each of R4 and R5 is independently H,>； = O, ORa, N (Ra) 2, N3, CN, S (O) nRa, halogen or haloalkyl (C1-C8)； each n is 0, 1 or 2； R6 is H, aryl, arylalkyl or ** Formula ** in which each of W1 and W2 is, independently, ORa or a group of Formula Ia: ** Formula ** in which: each Y is independently a bond or OR； M2 is 0, 1 or 2； Each Rx is H, halogen or OH.Un compuesto de Fórmula I:**Fórmula** o una sal, un solvato o un éster farmacéuticamente aceptables del mismo； en la que: cada uno de R1 y R7 es independientemente H, halógeno, ORa, haloalquilo (C1-C8), halocicloalquilo (C3-C8), CN, N3, alquilo (C1-C8), cicloalquilo (C3-C8), alquilo (C1-C8) sustituido,
