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REDUCED DOSE ORAL PHARMACEUTICAL COMPOSITIONS OF FENOFIBRATE
专利权人:
Venkat Reddy KALLEM
发明人:
Venkat Reddy KALLEM,Raghu Rami Reddy KASU,Subhasis DAS,Vijaya Kumar THOMMANDRU,Ninad DESHPANDAY
申请号:
US13350099
公开号:
US20130115246A1
申请日:
2012.01.13
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The invention relates to reduced dose oral pharmaceutical composition of fenofibrate which exhibits substantial bioequivalence to Antara® Capsules under fasting condition and also capable of reducing the food effect on bioavailability of fenofibrate. Provided is a pharmaceutical composition comprising about 90 mg of fenofibrate particles having a D90 particle size of less than about 600 nm and a pharmaceutically acceptable carrier, wherein the pharmaceutical composition is a solid dosage form suitable for oral administration and is substantially free of food effect such that when administered orally to a human provides an AUC0-t value for fenofibric acid in the blood plasma of the human under a fed state which is higher than the AUC0-t value under a fasted state by up to 12%, wherein t is 96 hours from the administration of the pharmaceutical composition.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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