Heterocyclylaminoalkyl substituted benzimidazoles

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专利权人:

Tibotec Pharmaceuticals Ltd

发明人:

Fortin, Jerome Michel Claude,Doublet, Frederic Marc Maurice,Muller, Philippe,Bonfanti, Jean-Francois

申请号：

AU2006260970

公开号：

AU2006260970B2

申请日:

2006.06.20

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

Heterocyclylaminoalkyl Substituted Benzimidazoles Inhibitors of RSV replicationof formula (I): The salts and stereochemically isomeric forms thereof, whereinQ is hydrogen, C1-6alkyl optionally substituted with a heterocycle or Q is C1-6alkyl substituted with both -OR4 and a heterocycle； wherein said heterocycleis oxazolidine, thiazolidine, 1-oxo-thiazolidine, 1,1-dioxothiazolidine,morpholinyl, thiomorpholinyl, 1-oxo-thiomorpholinyl, 1,1-dioxothiomorpholinyl,hexahydrooxazepine, hexahydrothiazepine, 1-oxo-hexahydrothiazepine,1,1-dioxo-hexahydrothiazepine, pyrrolidine, piperidine, homopiperidine,piperazine； which heterocyle may be substituted with 1-2 substituents； eachAlk is C1 -6alkanediyl； R1 is Ar or optionally substituted piperidinyl, piperazinyl,morpholinyl, thiomorpholinyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl,furanyl, tetrahydrofuranyl, thienyl, pyrrolyl, thiazolyl, oxazolyl, imidazolyl,isothiazolyl, pyrazolyl, isoxazo lyl, oxadiazolyl, quinolinyl, quinoxalinyl,benzofuranyl, benzothienyl, benzimidazolyl, benzoxazolyl, benzthiazolyl,pyridopyridyl, naphthiridinyl, 1H-imidazo[4,5-b]pyridinyl, 3H-imidazo[4,5-b]pyridinyl,imidazo[1,2-a]pyridinyl or 2,3-dihydro-1,4-dioxino[2,3-b]pyridyl； R3is hydroxyC1 -6alkyl, C1 -6alkoxyC1-6alkyl, cyanoC1-6alkyl, aminocarbonyl-C1-6-alkyl, mono-or di(C1 -6alkyl)aminocarbonyl-C1 -6- alkyl, carboxyl-C1-6-alkyl, C1-6alkoxycarbonyl-C1-6 alkyl； R2, R4 and R5 are hydrogen or C1-6alkyl；Het is pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl, furanyl, tetrahydrofuranyl,thienyl, pyrrolyl, thiazolyl, oxazolyl, imidazolyl, isothiazolyl, pyrazolyl,isoxazolyl, oxadiazolyl, quinolinyl, quinoxalinyl, benzofuranyl, benzothienyl,benzimidazolyl, benzoxazo lyl, benzthiazolyl, pyridopyridyl, naphthiridinyl,1H-imidazo[4,5-b]- pyridinyl, 3H-imidazo[4,5-b]pyridinyl, imidazo[1,2-a]pyridinyland 2,3-dihydro-1,4- dioxino[2,3-b]pyridyl； Ar is optionally substitut

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