КОННОЛЛИ Питер Дж. (US),БИАН Хайан (US),ЛИ Сюнь (US),ЛЮ Ли (US),МЭСИЛАГ Марк Дж. (US),МАКДОННЕЛЛ Марк Е. (US)
申请号：
RU2013123275/04
公开号：
RU2013123275A
申请日:
2011.10.20
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. The compound of formula (I) formula (I) where Y and Z are independently selected from group a) or group b) such that one of the elements (Y or Z) is selected from group a) and the other from group b)； group a) is i) C-aryl not substituted or substituted by a substituent selected from the group consisting of fluoro, chloro, C-alkyl, C-alkoxyl, cyano and trifluoromethyl； or ii) an unsubstituted heteroaryl selected from the group consisting of thiazolyl, isothiazolyl and 1H-pyrrolyl； group b) is i) C-aryl； ii) a heteroaryl selected from the group consisting of benzoxazolyl, benzothiazolyl, benzimidazolyl, benzothienyl, indazolyl and indolyl； iii) phenylmethylphenyl in which the phenyl group of the phenylmethyl has no substituent or is substituted with trifluoromethyl or fluorine； or iv) 1,3-dihydro-3H-benzimidazol-2-onyl； wherein members of group b) other than phenylmethylphenyl have no substituents or are substituted with one or two substituents independently selected from the group consisting of bromine, chlorine, fluorine, iodine, C-alkyl, C-alkoxyl and R； subject to the presence of not more than one substituent R； and R is selected from the group consisting of trifluoromethyl, 2,2,2-trifluoroethyl, 3,3,3-trifluoropropyl, 4,4-difluorocyclohexyl, thienyl, pyridinyl and phenyl； moreover, these thienyl, pyridinyl and phenyl in R do not have substituents or are substituted by one or two substituents independently selected from the group consisting of trifluoromethyl, methyl, chlorine, cyano and fluorine； R is hydrogen or hydroxy； and also its enantiomers, diastereomers, solvates and pharmaceutically acceptable salts. 2. The compound according to claim 1, in which group a) is non-substituted phenyl or non-substituted�1. Соединение формулы (I)формула (I)гдеY и Z независимо выбраны из группы a) или группы b) таким образом, что один из элементов (Y или Z) выбран из группы a), а другой - из группы b)；группа a) представляет собойi) C-арил, не имеющий заместителя или замеще
