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ヘテロシクリルアミノアルキル置換ベンズイミダゾール
专利权人:
テイボテク・フアーマシユーチカルズ
发明人:
ボンフアンテイ,ジヤン-フランソワ,ミユラー,フイリツプ,フオルタン,ジエローム・ミシエル・クロード,ドウブレ,フレデリク・マルク・モーリス
申请号:
JP2008517488
公开号:
JP5094716B2
申请日:
2006.06.20
申请国别(地区):
JP
年份:
2012
代理人:
摘要:
[Formula 1] Wherein formula (I) Q is C 1 substituted in both the heterocyclic base and -OR 4 is Q or a C 1-6 alkyl which may be substituted with a heterocycle of hydrogen, optionally There -6 alkyl here heterocycle oxazolidine, thiazolidine, 1-oxo - thiazolidine, 1,1-di-oxo-thiazolidine, morpholinyl, thiomorpholinyl, 1-oxo - thiomorpholinyl, 1,1-dioxothiomorpholinyl , hexa-hydro-oxy azepine, hexahydro-benzothiazepine, 1-oxo - hexahydro-benzothiazepine 1,1-dioxo - hexahydro-benzothiazepine, pyrrolidine, piperidine, homopiperidine, is a piperazine, the heterocyclic ring is one or two There Alk Each 1-6 alkanediyl C R 1 or Ar, may piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, pyridyl, pyrazinyl, pyridazinyl and optionally substituted optionally may be substituted with a substituent , pyrimidinyl, furanyl, tetrahydrofuranyl, thienyl, pyrrolyl, thiazolyl, oxazolyl, imidazolyl, isothiazolyl, pyrazolyl, isoxazolyl, oxadiazolyl, quinolinyl, quinoxalinyl, benzofuranyl, benzothienyl, benzimidazolyl, benzoxazolyl, benzthiazolyl, pyridopyridyl, naphthyridinyl, 1H - or imidazo [1,2-a] pyridinyl imidazo [4,5-b] pyridinyl, 3H- imidazo [4,5-b] pyridinyl, 2,3-dihydro 1,4 dioxino [2,3-b a] pyridyl there R 3 is hydroxy C 1-6 alkyl, C 1-6 alkoxy C 1-6 alkyl, cyano-C 1-6 alkyl, amino carbonyl C 1-6 alkyl, mono - or di (C 1-6R 5 and 2, R 4 R is C 1-6 alkyl or hydrogen There alkyl) aminocarbonyl -C 1-6 alkyl, alkyl carboxyl -C 1-6, 1-6 alkyl C 1-6 alkoxycarbonyl -C is Het is pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl, furanyl, tetrahydrofuranyl, thienyl, pyrrolyl, thiazolyl, oxazolyl, imidazolyl, isothiazolyl, pyrazolyl, isoxazolyl, oxadiazolyl, quinolinyl, quinoxalinyl, benzofuranyl, benzothienyl, benzimidazolyl, Benzookisa imidazo [1,2-a] pyridinyl thiazolyl, benzthiazolyl, pyridopyridyl, naphthyridinyl, 1H- imidazo [4,5-b] pyridinyl, 3H- imidazo [4,5-b] pyridinyl, 2,3-dihydro-1 There 4 dioxino a [2,3-b] pyridyl RSV replication inhibitor heterocyclylaminoalkyl substituted be
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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