JANSSEN R & D IRELAND;JANSSEN SCIENCES IRELAND UC;TIBOTEC PHARMACEUTICALS LTD.;TIBOTEC PHARMACEUTICALS
发明人:
Frédéric Marc Maurice Doublet,Jean-François Bonfanti,Jérôme Michel Claude Fortin,Philippe Muller
申请号：
BRPI0612317
公开号：
BRPI0612317B1
申请日:
2006.06.20
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
2-substituted benzimidazoles. The present invention relates to (rsv) replication inhibitors of formula (i), to the addition salts and stereochemically isomeric forms of such inhibitors, wherein q is hydrogen, C1-6-alkyl optionally substituted by a heterocycle or q is C 1-6 alkyl substituted by either -or 4 or a heterocycle or q is C 1-6 alkyl substituted by either -or 4 or a heterocycle； wherein said heterocycle is oxazolidine, thiazolidine, 1-oxo-thiazolidine； 1,1-dioxothiazolidine, morpholine, thiomorpholinyl, 1-oxo-thiomorpholinyl, 1-1-dioxothiomorpholinyl, hexahydroxyazepine, hexahydro-thiazepine, 1-oxohexahydrothiazepine, 1,1-dioxohexothiazepine, pyrrolidine, piperidine, piperidine, piperidine, which heterocycle may be substituted by 1-2 substituents； each is C 1-6 alkanediyl； R ^ 1 ^ is ar ^ 2 ^ or piperidinyl, piperazinyl, morphonyl, thiomorpholinyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl, furanyl, tetrahydrofuranyl, thienyl, pyrrolyl, thiazolyl, oxazolyl, imidazolyl, isothiazolyl, oxazolyl, quinazoline, quinoxalinyl, benzofuranyl, benzothienyl, benzimidazolyl, benzoxazolyl, benzthiazolyl, pyridopyridyl, naphthyridinyl, 1h-imidazo [4,5-b] pyridinyl, 3h-imidazo [4,5-b] pyridinyl, imidazo [1,2-a] pyridinyl or 2,3-dihydro-1,4-dioxino [2,3-b] pyridyl； R3 is hydroxy-1-6-alkyl, ar-2-4, ar-2-4-c1-6-alkyl, C1-6-alkylcarbonyl, ar-2-4-carbonyl, ar-2-2-c2 1-6-alkylcarbonyl, C 1-6 -alkylsulfonyl, aminosulfonyl, ar-1-4-alkylsulfonyl, ar-1-6-alkylsulfonyl, C 1-6-alkyloxy-1-6-alkyl, aminocycline 1-6-alkyl, C 1-6-alkylaminocarbonyl, C-1-6-alkyloxycarbonyl-1-6-alkyl, hydroxycarbonyl-1-6-alkyl, aminosulfonyl-1-6-alkyl, het, het-c 1-6-alkyl, het-carbonyl, het-sulfonyl, het-C 1-6-alkylsulfonyl and het-C 1-6-alkylcarbonyl； het is an optionally substituted heterocycle； pharmaceutical compositions containing compounds (i) and processes for preparing compounds (i).benzimidazóis 2-substituídos. a presente invenção refere-se a inibidores de replicação de (rsv) de fórmula (i), ao
