BALDINO Karmen M. (US),БАЛДИНО Кармен М. (US),KASERTA Dzhastin L. (US),КАСЕРТА Джастин Л. (US),LI Chi-Seng (US),ЛИ Чи-Сенг (US),NAJSVONDZHER Robert B. (US),НАЙСВОНДЖЕР Роберт Б. (US),FLANDERS Ivonn L.,ФЛАНДЕРС Ивонн Л. (US),ДЮМА Стефан А. (US)
申请号：
RU2012131082
公开号：
RU0002636589C2
申请日:
2010.12.23
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
FIELD: pharmacology.SUBSTANCE: invention relates to a compound of formula 2 ,wherein independently for each case R1 is hydrogen； each R2 and R3 is independently selected from the group consisting of hydrogen； (C1-C6)alkyl, optionally substituted with OH； heteroaryl containing 6 atoms in the ring, 1 atom of which is N, and the remaining ones are C atoms (pyridine)； heterocyclyl containing 5 or 6 ring atoms, 1 atom of which is N and the remaining ones are C atoms (piperidine or pyrrolidine) optionally substituted by a group selected from methyl, phenyl, pyridinylmethyl, quinolinylmethyl, pyridinylmethyl, piperidinylmethyl or azetidinylmethyl； aryl (C1-C6)alkyl, wherein aryl contains 6 ring atoms, optionally substituted amino or CH2NH2, where (C1-C6)alkyl is optionally substitutedby OH； heteroaryl (C1-C6)alkyl, wherein heteroaryl contains 5 to 9 ring atoms, of which 1 to 2 are heteroatoms selected from N and S, and the remaining atoms are C atoms (indole, pyridine, thiophene, benzimidazole, pyrazole), wherein heteroaryl is optionally is replaced by ethyl； heterocycle (C1-C6)alkyl, wherein the heterocycle contains 6 ring atoms, 1 atom of which is N and the remaining ones are C atoms (piperidine) optionally substituted by methyl； and - [C(R4)2]p-R5, or R2 and R3 are joined together to form an optionally substituted heterocyclic ring containing 5-10 atoms, of which 1 to 2 are heteroatoms selected from N and O, and the remaining ones are C atoms； R20 is selected from the group consisting of hydrogen； heterocyclyl containing 6 ring atoms, 1 atom of which is a heteroatom selected from N, and the remaining atoms are C atoms (piperidinyl)； halogen (C1-C6)alkyl； trifluoromethyl； fluorine (C1-C6)alkyl； -O-[C(R4)2]p-R5； -OR16, where R16 is methyl； and amino, which is -N(R50)(R51), where each R50 and R51 is independently hydrogen, (C1-C6)alkyl, optionally substituted by methoxy, or - (CH2)m-R61, where R61 is an aryl containing 6 ring atoms, and m is an integer from 1 to 8. The in
