BRESLIN, MICHAEL J.,COLEMAN, PAUL J.,COX, CHRISTOPHER D.,SCHREIER, JOHN D.
申请号：
ES08754659
公开号：
ES2379744T3
申请日:
2008.05.22
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of formula I: in which: A is selected from the group consisting of phenyl, naphthyl and heteroaryl； R1a, R1b and R1c may be absent if the valence of A does not allow such substitution and is independently selected from the group consisting of: (1) hydrogen, (2) halogen, (3) hydroxyl (4) - (C = O) m-On-C1-C6 alkyl, in which m is 0 or 1, n is 0 or 1 (in which if m is 0 on is 0, there is a bond present) and in which the alkyl is without replace or substituted with one or more substituents selected from R13, (5) - (C = O) m-On-cycloalkyl (C3-C6), in which the cycloalkyl is unsubstituted or substituted with one or more substituents selected from R13 , (6) - (C = O) m-alkenyl (C2-C4), in which the alkenyl is unsubstituted or substituted with one or more substituents selected from R13, (7) - (C = O) m-alkynyl (C2-C4), in which the alkynyl is unsubstituted or substituted with one or more substituents selected from R13, (8) - (C = O) m-On-phenyl or - (C = O) m-On- naphthyl, in which the phenyl or naphthyl is unsubstituted or substituted with one or more selected substituents of R13, (9) - (C = O) m-On-heterocycle, in which the heterocycle is unsubstituted or substituted with one or more substituents selected from R13, (10) - (C = O) m-NR10R11, wherein R10 and R11 are independently selected from the group consisting of: (a) hydrogen, (b) (C1-C6) alkyl, which is unsubstituted or substituted with R13, (c) (C3-C6) alkenyl, which is unsubstituted or substituted with R13, (d) (C3-C6) alkynyl, which is unsubstituted or substituted with R13, (e) cycloalkyl (C3-C6) that is unsubstituted or substituted with R13, (f) phenyl, which is unsubstituted or substituted with R13 and (g) heterocycle, which is unsubstituted or substituted with R13, (11) -S (O) 2-NR10R11, (12) -S (O) q-R12, in which q is 0, 1 or 2 and in which R12 is selected from the definitions of R10 and R11, (13) -CO2H, (14) -CN and (15) -NO2； R2a, R2b and R2c are independently selected from the group consisting of
