COOPER MARTIN,RECEVEUR JEAN-MARIE,HOEGBERG THOMAS,NIELSEN PETER AADAL,LINGET JEAN-MICHEL,NOEREGAARD PIA KARINA,MURRAY ANTHONY,BJURLING EMELIE
申请号：
IN4178/CHENP/2009
公开号：
IN2009CN04178A
申请日:
2009.07.16
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
ABSTRACT Compounds of formula (l) suppress the nomral signaling activity CB1 receptor and are... thus useful in the treatment of diseases or conditions are mediated by. CB1 receptor -signalling activity such as treatment of obesity and overweight, prevention weight gain, . treatment of. diseases and conditions directly, or indirectly associated with obesity an overweight wherein Ar is hydrogen,-COOH, or tetrazolyl and-A2 is hydrogen -COOH, or tetrazolyl, provided, that one of A1 and A2 is either-COOH or tetrazoyl p is 0 or 1 and A3 is phenyl or cycloalkyl, either of which is optionally substituted with R4 and or R5 q is 0 or 1 R3 is hydrogeen C1-C4 alkyl,cycloalkyl is ,-CF3,or-OR3 R4 and R5 independently-R5, -CN-F,-Cl-Br, -OR9- NR7R6-NR7-COR6.- NR7SO2R6-COR6, -SR3. -SOR6 ,or-SO2-R4 is C1-C4 alkyl, cycloalkyl , -CF3 or-NR7 R6 R7 and R6 are independendy hydrogen, C1-C4.alkyl .- or cycloalkyl, R4 is hydrogen, C1-C4 alkyl, cyctoalkyl, {fully or partially fluorinated C1-C4 alkyl R1 is (i) a bond, or (ii) -(CH2)aB,(CH2)b- wherein a and b are independently 0,1, 2 or 3 provided that a+b is 1,2 or 3or(iii)-C
