ORTEGA-MUNOS Alberto (ES),ОРТЕГА-МУНЬОС Альберто (ES),FAJF Mattyu Kolin Tor (ES),ФАЙФ Маттью Колин Тор (ES),MARTINEL-PEDEMONTE Mark (ES),МАРТИНЕЛЬ-ПЕДЕМОНТЕ Марк (ES),ESTYARTE-MARTINES Mariya-de-los-A
申请号：
RU2014119976
公开号：
RU0002668952C2
申请日:
2012.10.22
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
FIELD: pharmaceuticals.SUBSTANCE: invention relates to a novel (hetero)aryl cyclopropylamine compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the substituents of the cyclopropyl moiety -A-B and -NH-D can be in the trans-configuration or a compound can be an optically active stereoisomer. In the compound of formula IA is phenyl, naphthyl, pyridyl, thiophenyl, pyrrolyl, furanyl, or thiazolyl, wherein said phenyl, said naphthyl, said pyridyl, said thiophenyl, said pyrrolyl, said furanyl, or said thiazolyl is optionally substituted with one or more R1； B is hydrogen, R1 or -L-E； E is phenyl, pyridinyl, pyrazolyl or indazolyl, wherein said phenyl, said pyridinyl, said pyrazolyl or said indazolyl is optionally substituted with one or more R2； L is a bond, -O-, -NH-, -CH2-NH- or -CH2-O-, where said groups -CH2-NH- and -CH2-O- are linked to ring A via the N or O atom, respectively and are linked to ring E via the -CH2- group contained in said groups -CH2-NH- and -CH2-O-； D is selected from D1, D2, D3 and D4:,where a cyclobutyl ring contained in D1, cyclopentyl ring contained in D2, cyclohexyl ring contained in D3, and cycloheptyl ring contained in D4, is optionally substituted with one or more R4； each R1 is independently selected from the group consisting of halogen, C1-C4-alkyl, halogen-C1-C4-alkyl, C1-C4-alkoxy group and C3-C6-cycloalkyl； each R2 is independently selected from the group, including C1-C8-alkyl, a hydroxy group, halogen, halogen-C1-C8-alkyl, halogen-C1-C8-alkoxy group, cyano group, N-sulfonamide group and C1-C8-alkoxy group； R3 is selected from a group comprising -NR7R8 and –C1-C4-alkylene-NR7R8； each R4 is independently selected from the group consisting of C1-C8-alkyl, halogen, halogen-C1-C8-alkyl, halogen-C1-C8-alkoxy group and C1-C8-alkoxy group； each R7 and each R8 is independently selected from the group consisting of hydrogen, C1-C8-alkyl, R12R13N-C1-C8-alkyl and hydroxy-C1-C8-alkyl, or R7 and R8 are linked to each othe
