КАТАЛАНО Сьюзан М.,РИШТОН Гилберт,ИЗЗО Николас Дж.
申请号：
RU2014111079
公开号：
RU2014111079A
申请日:
2012.08.27
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A compound of formula I: wherein R independently suitably selected from H, OH, halogen, C-alkoxy, C-haloalkyl, C-haloalkoxy, (R) (R) N-Calkilen-O-, r and Rsoedineny or to form a group - O-ethylene-O-, wherein R independently represent way C-alkyl or benzyl, or R Rsovmestno with the nitrogen atom form a ring selected izigde X represents N or O, and R is H or unsubstituted phenyl and wherein at least one of R Rne is H R c is selected izgde R, R, R, r and independently suitably selected from H, halogen, C-alkyl, C-alkoxy, haloalkyl, and S (O) -C-alkyl R is H and n is 1-4 R is Ci ^ alkyl R is H or Ci ^ alkyl iRpredstavlyaet is H, C-alkyl and C (O) O (C-alkyl), C (O) (C-alkyl), or C (O) (C-haloalkyl) iliRi Rsovmestno with the nitrogen atom form a ring selected izigde r and independently suitably selected from H, halogen and C-haloalkyl, and Y represents CH or N R is H, Ci ^ alkyl, C-cycloalkyl, unsubstituted phenyl or phenyl substituted with C-haloalkyl, or unsubstituted benzyl r and independently suitably selected from H and halo R is H, iego pharmaceutically acceptable salts thereof, subject to the exclusion of the following racemic mixtures of compounds: u2. A compound according to claim 1, characterized in that:. r and independently suitably selected from H, OH, halogen, C-alkoxy, C-haloalkyl, C-haloalkoxy, (R) (R) N-Calkilen-O-, or R1 and R2 join to form a group -O-ethylene-O-, wherein R manner independently represent Ci ^ alkyl or benzyl, iliRi Rsovmestno with the nitrogen atom form a ring selected izi where X is N or O, and Rotsutstvuet or represents H or unsubstituted phenyl and wherein at least one of R Rne is H R1. Соединение формулы I:где Rи Rнезависимым образом выбраны из H, OH, галогена, C-алкокси, C-галогеналкила, C-галогеналкокси, (R)(R)N-Cалкилен-O-, либо Rи Rсоединены с образованием группы -O-этилен-O-, гдеRи Rнезависимым образом представляют собой C-алкил или бензил, или Rи Rсовместно с атомом азота образуют кольцо, выбранное изигде X представляет
