HONARNEJAD, Kamran,DASCHNER, Alexander,HERMS, Jochen,BRACHER, Franz,KUZNICKI, Jacek,GEHRING, André Philipe
申请号：
EPEP2013/055969
公开号：
WO2013/139929A1
申请日:
2013.03.21
申请国别(地区):
WO
年份:
2013
代理人:
摘要：
This invention relates to a compound of formula (la) or (Ila) wherein either (A) R1 is I and R2 is selected from substituted or unsubstituted piperidinyl, preferably N-substituted or unsubstituted piperidin-4-yl substituted or unsubstituted cyclohexyl, cyclopentyl, or cyclohexyl alkyl substituted or unsubstituted aryl-alkyl alkyl aryl - CHO and hydrogen or (B) R1 is selected from halogen substituted or unsubstituted alkoxy substituted or unsubstituted alkyl cyano and hydrogen and R2 is substituted or unsubstituted piperidinyl, preferably N-substituted or unsubstituted piperidin-4-yl and R3, R4 and R5 independently are either H or defined as R1 R6 is H alkyl or aryl-alkyl, or R2 and R6 together with the N attached thereto form a 5- or 6-membered ring, preferably pyrrol each of the m occurrences of R7 is independently selected from C1 to C4 alkyl, C1 to C4 alkoxy and halogen, preferably F and m being 0, 1, 2, 3 or 4 X is selected from NH N-alkyl, preferably NCH3 N- aryl-alkyl S and O wherein in formula (la) R2 and X together may alternatively form or comprise a 6-membered ring, said 6-membered ring preferably being piperazine n is 0, 1 or 2 the substituents being independently selected from alkyl, aryl-alkyl alkoxy, aryl, hydroxy halogen oxo and thio alkyl being branched, unbranched and/or cyclic C1 to C10 alkyl, preferably branched or unbranched C1 to C4 alkyl, more preferably methyl, ethyl, n-propyl, i- propyl, i-butyl or t-butyl alkoxy being C1 to C4 alkoxy, preferably methoxy aryl being phenyl, naphthyl or tetrahydronaphthyl, preferably phenyl or a compound of any one of Tables 3 to 46 or a salt or hydrate thereof.La présente invention concerne un composé de formule (la) ou (Iia) dans laquelle soit (A) R1 est I et R2 est choisie parmi la pipéridinyle, substituée ou non substituée de préférence pipéridin -4-yl N-substituée ou non substituée cyclohexyle substitué ou non substitué, cyclopentyle, ou cyclohexyle alkyle aryl-alkyle substitué ou non substitué alkyle aryl
