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Benzodioxol derivative and method of preparation and use thereof
专利权人:
Zhejiang Hisun Pharmaceutical Co. Ltd.
发明人:
BAI, Hua,ZHAO, Xuyang,ZHONG, Jinqing,GONG, Yongxiang,ZHU, Qifeng,LIU, Xiaoyu,ZHENG, Xiaohe,LIU, Lifei
申请号:
ES13813363
公开号:
ES2645643T3
申请日:
2013.07.03
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound represented by formula (I): ** Formula ** or a pharmaceutically acceptable salt, wherein: R1 and R2 are independently selected from the group consisting of hydrogen, methyl and ethyl; R1 and R2 together can be>; = O; also, R1 and R2 together with the connecting carbon atom can form a 3-membered carbon ring; A is selected from the group consisting of phenyl, phenyl substituted with R3, pyridinyl, pyridinyl substituted with R4, pyrimidinyl, pyrimidinyl substituted with R5, pyrrolyl, pyrrolyl substituted with R6, pyridazinyl, pyridazinyl substituted with R7, pyrazolyl and pyrazolyl substituted with R8; R3 is 1 to 5 substituents independently selected from the group consisting of halogen, (C1-C3) alkyl, (C2-C3) alkenyl, (C3-C4) cycloalkyl, (C1-C3) alkoxy, trifluoromethyl and cyano; R4 is 1 to 4 substituents independently selected from the group consisting of halogen, (C1-C3) alkyl, (C2-C3) alkenyl, (C3-C4) cycloalkyl, (C1-C3) alkoxy, trifluoromethyl and cyano; R5 is 1 to 3 substituents independently selected from the group consisting of halogen, (C1-C3) alkyl, (C2-C3) alkenyl, (C3-C4) cycloalkyl, (C1-C3) alkoxy, trifluoromethyl and cyano; R6 is 1 to 4 substituents independently selected from the group consisting of (C1-C3) alkyl, (C2-C3) alkenyl, and (C3-C4) cycloalkyl; R7 is 1 to 3 substituents independently selected from the group consisting of halogen, (C1-C3) alkyl, (C2-C3) alkenyl, (C3-C4) cycloalkyl, (C1-C3) alkoxy, trifluoromethyl and cyano; R8 is 1 to 3 substituents independently selected from the group consisting of (C1-C3) alkyl, (C2-C3) alkenyl, and (C3-C4) cycloalkyl.Un compuesto representado por la fórmula (I):**Fórmula** o una sal farmacéuticamente aceptable, en donde: R1 y R2 se seleccionan independientemente del grupo que consiste en hidrógeno, metilo y etilo; R1 y R2 juntos pueden ser >;= O; también, R1 y R2 junto con el átomo de carbono que los conecta pueden formar un anillo de carbono de 3 miembros; A se selecciona del grupo que consis
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