The problem of the present invention is to provide a useful compound as a glucokinase activating agent, which is the oxime derivative of the formula [I]: wherein Ring A is aryl or heteroaryl； Q is cycloalkyl, heterocycle, alkyl or alkenyl； Ring T is heteroaryl or heterocycle； R1 and R2 are independently hydrogen atom, halogen atom, cycloalkylsulfonyl or the like； R3 and R4 are independently hydrogen atom, hydroxy, oxo, halogen atom or the like； R5 is hydrogen atom, halogen atom, cyano, nitro, tetrazolyl or the like； or a pharmaceutically acceptable salt thereof.本發明提供一種適用為葡糖激酶活化劑之化合物，其係如下式[I]肟衍生物或其醫藥上可接受之鹽其中A環為芳基或雜芳基；Q為環烷基、雜環、烷基或烯基；T環為雜芳基或雜環；R1與R2獨立地為氫原子、鹵原子、環烷基磺醯基等等；R3與R4獨立地為氫原子、羥基、酮基、鹵原子等等；R5為氫原子、鹵原子、氰基、硝基、四唑基等等。
