The present invention is directed to a useful compound as aglucokinase activating agent, which is the oxime derivative of theformula [I]:(see formula I)wherein Ring A is aryl or heteroaryl； Q is cycloalkyl, heterocycle, alkylor alkenyl； Ring T is heteroaryl or heterocycle； R1 and R2 areindependently hydrogen atom, halogen atom, cycloalkylsulfonyl or thelike； R3 and R4 are independently hydrogen atom, hydroxy, oxo, halogenatom or the like； R5 is hydrogen atom, halogen atom, cyano, nitro,tetrazolyl or the like； or a pharmaceutically acceptable salt thereof.
