The problem of the present invention is to provide a useful compound as a glucokinase activating agent, which is the oxime derivative of the formula [I]:wherein Ring A is aryl or heteroaryl；Q is cycloalkyl, heterocycle, alkyl or alkenyl；Ring T is heteroaryl or heterocycle；R1 and R2 are independently hydrogen atom, halogen atom, cycloalkylsulfonyl or the like；R3 and R4 are independently hydrogen atom, hydroxy, oxo, halogen atom or the like；R5 is hydrogen atom, halogen atom, cyano, nitro, tetrazolyl or the like；or a pharmaceutically acceptable salt thereof.
