Aminoquinazolines as kinase inhibitors

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专利权人:

GlaxoSmithKline Intellectual Property Development Limited

发明人:

BURY, Michael,CASILLAS, Linda,CHARNLEY, Adam,DEMARTINO, Michael,DONG, Xiaoyang,EIDAM, Patrick,HAILE, Pamela,MARQUIS, Robert,RAMANJULU, Joshi,ROMANO, Joseph,SINGHAUS, Robert,SHAH, Ami,WANG, Gren

申请号：

ES12824263

公开号：

ES2615749T3

申请日:

2012.08.17

申请国别(地区):

ES

年份:

2017

代理人:

摘要：

A compound according to Formula (I): ** Formula ** in which: R1 is H, -SO2-C1-C4 alkyl, -CO-C1-C4 alkyl, or C1-C4 alkyl )； R2 is -SRa, -SORa, or -SO2Ra, wherein Ra is (C1-C6) alkyl, halo (C1-C6) alkyl, (C3-C7) cycloalkyl, 4-7 membered heterocycloalkyl, aryl or heteroaryl , wherein: said (C1-C6) alkyl is optionally substituted with one or two groups each independently selected from cyano, hydroxyl, (C1-C6) alkoxy, (C1-C6) alkoxy (C2-C6) alkoxy, - CO2H, -CO2-(C1-C4) alkyl, -SO2- (C1-C4) alkyl, (C3-C7) cycloalkyl, phenyl, 5-6 membered heteroaryl, 9-10 membered heteroaryl, 4-7 heterocycloalkyl members and (phenyl) (C1-C4 alkyl) amino-, wherein said cycloalkyl (C3-C7), phenyl, (phenyl) (C1-C4 alkyl) amino-, 5-6 membered heteroaryl, 9- heteroaryl 10-membered or 4-7-membered heterocycloalkyl is optionally substituted with 1-3 groups each independently selected from halogen, -CF3, hydroxyl, amino, (C1-C4 alkyl) amino-, (C1-C4 alkyl) (alkyl (C1-C4) amino-, (C1-C4) alkyl, phenyl-C1-C4 alkyl-, hydroxy-C1-C4 alkyl and (C1-C4) alkoxy, said cycloal (C3-C7) chyl or 4-7 membered heterocycloalkyl is optionally substituted with 1-3 groups each independently selected from halogen, -CF3, hydroxyl, amino, ((C1-C4) alkyl) amino-, ((C1-alkyl) -C4) (C1-C4 alkyl) amino-, (C1-C4) alkyl, phenyl-C1-C4 alkyl-, hydroxy-C1-C4 alkyl-, oxo and (C1-C4) alkoxy, and said aryl or heteroaryl is optionally substituted with 1-3 groups each independently selected from halogen, -CF3, hydroxyl, amino, ((C1-C4) alkyl-, ((C1-C4) alkyl ((C1-C4) alkyl amino-, (C1-C4) alkyl, phenyl (C1-C4) alkyl -, hydroxy (C1-C4) alkyl - and (C1-C4) alkoxy； R3 is H, halogen, hydroxy, (C1-C4) alkyl -, (C2-C4) alkenyl -, halo (C1-C4) alkyl -, (C1-C4) alkoxy -, halo (C1-C4) alkoxy -, (C1-C4) alkoxy-(C1-C6) alkyl -, halo (C1-C4) alkoxy (C1-C6) alkyl -, (C1-C4) alkoxy (C2-C6) alkoxy -, halo-alkoxy (C1-C4) (C2-C6) alkoxy -, hydroxy (C1-C6) alkyl -, hydroxy (C2-C6) alkoxy -, cyano-(C1-C4) alkyl -, cyano-alkoxy (C2-C6) ) -, carboxy-C1-C

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