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NEW COMPOUNDS AND THEIR THERAPEUTIC USE FOR INHIBITING PROTEINKINASE
专利权人:
ВУ Зхэнжжуи (US)
发明人:
ВУ Зхэнжжуи (US)
申请号:
RU2012109220/04
公开号:
RU2012109220A
申请日:
2010.09.17
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. The compound of formula I: where Y = NH, O, or S, R = is selected from the following groups: where X = CH, NH, S, or O, R = —H, —NH, —OH, —N (R , R), -C (RR) NRR, -C (RR) OR, or -N (R) NRR, where R, R, R, R = H, alkyl (C-C), cycloalkyl (CC) with nuclear with or without heteroatoms, such as O, S, and N, aryls (either unsubstituted or substituted aromatic hydrocarbons), or heteroaromatic hydrocarbons (either unsubstituted or substituted heteroaromatic hydrocarbons), R, R, R, R, and R = H, alkyls (C — C), cycloalkyls (C — C), with or without nuclear heteroatoms such as O, S or N; aryls (either unsubstituted or substituted aromatic hydrocarbons), or heteroaromatic hydrocarbons (either unsubstituted or substituted heteroaromatic hydrocarbons), R, is selected from the group consisting of H, OH, NH, OR, NRR, alkyl, aryl, heteroaryl, cycloalkyl, arylalkyl, heterocyclyl, heterocyclylalkyl, alkenyl, and alkynyl, where R, R = H, alkyls (C — C), cycloalkyls (C — C) with or without nuclear heteroatoms such as O, S, N, aryls (or unsubstituted or substituted aromatic hydrocarbons) or heteroaromatic hydrocarbons (or not optionally substituted or substituted heteroaromatic hydrocarbons), and R is selected from the group consisting of H, alkyl, aryl, heteroaryl, cycloalkyl, arylalkyl, heterocyclyl, heterocyclylalkyl, alkenyl, and alkynyl, in particular R is selected from the following groups: where R, R, and R are selected the following groups: H; a heteroatom such as F, Cl, Br, I; alkyl (C-C); cycloalkyl (C — C) without or with substitutions, where the substitution is selected from the group consisting of alkyls (C — C), cycloalkyls (C — C), aryls, heteroaryls; -OR; -SR; -NRR; -S (O) R; -S (O) R; -S (O) NRR; -C (O) NRR; -N (R) C (O) R; -N (R) S (O) R; -N (R) C (O) N (RR); N (R) C (O) OR; aryl with or without substitution, heteroaryl with or without substitution, aryalkyl with or without1. Соединение формулы I:где Y = NH, O, или S,R= выбран из следующих групп:где X = CH, NH, S, ил
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