Claimed is a pharmaceutical composition comprising an open matrix network carrying a pharmaceutically active ingredient such as desmopressin acetate, loratidine, famotidine, montelukast sodium or ondansetron, wherein the open matrix network comprises levan and inulin, and wherein the pharmaceutical composition has a tensile strength of about 0.05-1.6 N/mm2 and a rapid dissolution rate such that at least 80% of the composition is dissolved in an aqueous medium or saliva within 30 seconds, the matrix may also further comprise mannitol, trehalose and/or raffinose. Also disclosed is a process for the preparation of a pharmaceutical composition as defined above, the process comprising: (a) preparing a solution comprising levan, inulin and an active ingredient in a solvent； (b) freezing said solution； (c) subliming the solvent from the frozen solution.
