Disclosed herein is a pharmaceutical composition including a matrix carrying a pharmaceutically active ingredient, preferably desmopressin acetate, loratidine, famotidine, or montelukast sodium, wherein the matrix including inulin as a matrix forming agent and mannitol. Also disclosed is a process for the preparation of the above composition comprising: (a) preparing a solution comprising inulin and an active ingredient in a solvent； (b) freezing said solution； (c) subliming the solvent from the frozen solution, wherein the pharmaceutical composition so obtained is disintegrates within 10 seconds upon contact with an aqueous solution or with saliva.
