The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.本申請案係關於新穎經取代吲唑、其製備方法、其單獨或以組合形式用於治療及/或預防疾病之用途及其用於製備用以治療及/或預防疾病,尤其治療及/或預防以下疾病之藥物的用途:子宮內膜異位及子宮內膜異位相關之疼痛及其他子宮內膜異位相關之症狀,諸如痛經、性交困難、排尿困難及排糞困難;淋巴瘤;類風濕性關節炎;脊椎關節炎(尤其牛皮癬性脊椎關節炎及別赫切列夫氏疾病);紅斑狼瘡;多發性硬化症;黃斑變性;COPD;痛風;脂肪肝病症;胰島素抗性;贅生性病症;及牛皮癬。