The present application relates to the use of substituted indazoles for treatment and/or prophylaxis of allergic and/or inflammatory diseases in animals, especially for treatment and/or prophylaxis of atopic dermatitis, Flea Allergy Dermatitis, inflammatory bowel disease, osteoarthritis and inflammatory pain, non-infectious recurrent airway disease, insect hypersensitivity, asthma, respiratory disease, mastitis and endometritis in animals.本申請案係關於經取代之吲唑在動物中用於治療及/或預防過敏及/或發炎性疾病的用途,特別是在動物中用於治療及/或預防異位性皮膚炎、跳蚤過敏性皮膚炎、發炎性腸病、骨關節炎和發炎症性疼痛、非傳染性複發性氣道疾病、昆蟲超敏性、氣喘、呼吸道疾病、乳腺炎及子宮內膜炎。