Duncan Alexander HAY,Thomas Beauregard SCHOFIELD,Naomi WENT,Clive McCARTHY
申请号：
US16756416
公开号：
US20200239442A1
申请日:
2018.10.17
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention discloses bis(pentahydroxyhexyl)amino substituted 2-{[(3-amino-pyrazin-2-yl)formamido]methyl}-1H-1,3-benzodiazol-3-ium derivatives of formula (I) as inhibitors of ENaC and are of use in the treatment of respiratory diseases and conditions, skin conditions or ocular conditions, wherein the respiratory disease or condition is e.g. cystic fibrosis, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, bronchiectasis, including non-cystic fibrosis bronchiectasis, and asthma； the skin condition is e.g. psoriasis, atopic dermatitis and ichthyosis； and the ocular condition is e.g. dry eye disease.
