The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.本申請案係關於新穎經取代吲唑、其製法、其單獨或以組合方式於治療及/或預防疾病之用途及其於製備用於治療及/或預防疾病,尤其用於治療及/或預防子宮內膜異位症及與子宮內膜異位症相關聯之疼痛及其他的與子宮內膜異位症相關聯之症狀(諸如痛經、性交困難、排尿困難及排便困難)、淋巴瘤、類風濕性關節炎、脊柱關節炎(尤其係牛皮癬性脊柱關節炎及別赫捷列夫氏病(Bekhterev's disease))、紅斑狼瘡、多發性硬化症、黃斑變性、COPD、痛風、脂肪肝病、胰島素抗性、腫瘤性疾病及牛皮癬之藥劑之用途。