The present application relates to substituted indazoles, to the use thereof alone or in combinations for treatment and/or prophylaxis of autoimmune disorders, and to the use thereof for production of medicaments for treatment and/or prophylaxis of autoimmune disorders, especially for treatment and/or prophylaxis of arthritides (especially psoriatic arthritis, rheumatoid arthritis, Bekhterev's disease, reactive arthritis, systematic juvenile idiopathic arthritis), systematic lupus erythematosus, multiple sclerosis, psoriasis, atopic dermatitis, allergic eczema and chronic-inflammatory bowel disorders (especially Crohn’s disease and ulcerative colitis).本申請案係關於經取代之吲唑，其單獨或組合用於治療及/或預防自體免疫病症之用途，及其用於製造用來治療及/或預防自體免疫病症、尤其用來治療及/或預防關節炎(尤其牛皮癬性關節炎、類風濕性關節炎、別赫捷列夫氏病(Bekhterev's disease)、反應性關節炎、全身性幼年型特發性關節炎)、全身性紅斑狼瘡、多發性硬化、牛皮癬、異位性皮膚炎、過敏性濕疹及慢性發炎性腸病(尤其克隆氏病(Crohn’s disease)及潰瘍性結腸炎)之藥劑的用途。
