Gregory Kapp,Laura Serwer,Natacha Le Moan,Stephen P. L. Cary
申请号：
US16450913
公开号：
US10766947B2
申请日:
2019.06.24
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention provides polymeric H-NOX proteins for the delivery of oxygen with longer circulation half-lives compared to monomeric H-NOX proteins. Polymeric H-NOX proteins extravasate into and preferentially accumulate in tumor tissue for sustained delivery of oxygen. The invention also provides the use of H-NOX proteins as radiosensitizers for the treatment of brain cancers.
