Kapp, Gregory,Serwer, Laura,Le Moan, Natacha,Cary, Stephen
申请号:
NZ70982513
公开号:
NZ709825A
申请日:
2013.01.07
申请国别(地区):
NZ
年份:
2019
代理人:
摘要:
The invention provides polymeric H-NOX proteins for the delivery of oxygen with longer circulation half-lives compared to monomeric H-NOX proteins. Polymeric H-NOX proteins extravasate into and preferentially accumulate in tumor tissue for sustained delivery of oxygen. The invention also provides the use of H- NOX proteins as radiosensitizers for the treatment of brain cancers.