The present invention provides that a series of novel malonamide derivatives based on the skeleton of malonic acid were synthesized and their bioactivities against bacterial cell, bacterial-infected C. elegans and mice were evaluated.本發明提供合成一系列基於丙二酸的骨架的新穎丙二醯胺衍生物,及評估其對細菌細胞、細菌感染的線蟲和小鼠的生物活性。