YANG, ZHEN,杨震,楊震,TZENG, YEW MIN,曾耀铭,曾耀銘,LI, CHUANG-CHUANG,李闯创,李闖創,LUO, TUO-PING,罗佗平,羅佗平,SHI, HANG,石航,石航,YEH, CHI TAI,叶淇台,葉淇臺
申请号：
TW100128266
公开号：
TWI433841B
申请日:
2011.08.09
申请国别(地区):
TW
年份:
2014
代理人:
摘要：
The present invention provides a method of synthesizing antrocin. Development of a gold-catalyzed tandem reaction of 1,7-diynes with an internal and an external nucleophiles was realized, which constructed three chemical bonds, two rings and two stereogenic centers in a single step. Based on the novel cascade transformation, the present invention achieved a unified strategy towards the stereoselective total synthesis of antrocin. In addition, the present invention also provides a use of a composition for the inhibition of human non-small cell lung cancers, comprising an effective amount of antrocin or pharmaceutically acceptable salts thereof, together with a pharmaceutically acceptable carrier.本發明提供一種製備安卓幸(antrocin)的方法,其特色是基於金催化的串聯環化反應一步驟構建了[6-6-5]三環核心骨架。本發明還提供一種組合物在製備用於抑制非小細胞肺癌細胞生長的藥物中的應用,該組合物包含有效劑量的安卓幸或其醫藥上可接受鹽類與醫藥上可接受載體。
